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目的:对水杨酸溶出度校正片的溶出特性进行考察,提高标定化方案的操作性。方法:溶出仪校正合格后,将中国药品生物制品检定所提供的水杨酸溶出度校正A样和水杨酸溶出度校正B样各分别采用转篮法、桨法、小杯法测定在10,15,20,25和30min的溶出量。结果:以时间为横坐标,平均溶出量为纵坐标,绘制的溶出曲线线性关系良好,其相关系数(r)均达到0.999以上。
Objective: To investigate the dissolution characteristics of salicylic acid dissolution correction tablets and to improve the operability of the calibration protocol. Methods: Dissolution instrument calibration is qualified, the Chinese medicine and biological products provided by the calibration of salicylic acid solution-like and salicylic acid dissolution calibration B samples were used basket method, paddle method, small cup method in 10 , 15, 20, 25 and 30 min. Results: With the time as the abscissa and the average dissolution as the ordinate, the linearity of the dissolution curve was good, and the correlation coefficient (r) was above 0.999.