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目的研究盐酸氨溴索对急性呼吸窘迫综合征(ARDS)患者血清 IL-1β、IL-6、IL-8、IL-10、GM-CSF、TNF-α浓度及动脉血气的影响。方法选择 ARDS 患者40例,随机分成对照组(A 组,n=20)和实验组(B 组,n=20)。A 组给予单纯生理盐水500 ml 静脉滴注,B 组给予沐舒坦20 mg/kg+生理盐水500 ml 静脉滴注,共7 d。比较两组患者治疗前、治疗第5 d 和治疗第7 d 血清细胞因子浓度及动脉血气方面的变化和差异。结果用药7 dB 组患者的血清 IL-1β、IL-6、IL-8、GM-CSF,TNFα浓度明显降低,血清 IL-10浓度显著升高(P<0.05),血气指标明显改善(P<0.05),与 A 组比较均有显著性差异(P<0.05)。结论临床应用盐酸氨溴索可抑制 ARDS 患者促炎细胞因子的生成,而促进其抗炎细胞因子的产生,有利于其呼吸功能的恢复。
Objective To investigate the effects of ambroxol hydrochloride on serum IL-1β, IL-6, IL-8, IL-10, GM-CSF and TNF-α levels and arterial blood gas in patients with acute respiratory distress syndrome (ARDS) Methods Forty patients with ARDS were randomly divided into control group (A group, n = 20) and experimental group (B group, n = 20). Group A was given 500 ml saline infusion, Group B was given ambroxol 20 mg / kg + 500 ml saline infusion, a total of 7 days. The changes and differences of serum cytokine concentration and arterial blood gas between the two groups before treatment, the 5th day of treatment and the 7th day of treatment were compared. Results Serum levels of IL-1β, IL-6, IL-8, GM-CSF and TNFα in 7 dB group were significantly decreased, serum IL-10 concentration was significantly increased (P < 0.05), there was significant difference compared with A group (P <0.05). Conclusion Ambroxol hydrochloride can inhibit the production of proinflammatory cytokines in ARDS patients and promote the production of anti-inflammatory cytokines, which is beneficial to the resumption of respiratory function.