论文部分内容阅读
目的:探讨血清同型半胱氨酸(HCY)、C反应蛋白、纤维蛋白原(Fib)、白细胞(WBC)与冠心病(CHD)病变程度的相关性和作为检测指标的敏感性;检测BMI是否为CHD的独立风险因子。方法:测定102例不同类型冠心病患者和33例健康的HCY、CRP、Fib、WBC的水平,比较AMI.UAP.SAP组和对照组间各项指标的差异。结果:BMI>24和BMI<24两组中AMI、UAP、SPA和Control的构成比的差别,结果显示男性患者中两组构成有明显差异(P=0.011);女性患者中两组构成没有明显差异(P=0.28)。各组的HCY、CRP、Fib和WBC的水平为:AMI组大于UAP组大于SAP组大于对照组,AMI组与UAP组相比,差异有统计学意义(均为P<0.01),UAP组与SAP组相比,差异有统计学意义(P<0.05,P<0.01)。CRP和WBC的诊断价值较好,HCY和Fib的诊断价值中等。结论:同型半胱氨酸、C反应蛋白、纤维蛋白原和白细胞水平变化与冠心病的发生、发展密切相关,它们的四个指标可作为区别冠心病类型和评价其病变严重程度的辅助性指标。
Objective: To investigate the correlation between serum homocysteine (HCY), C-reactive protein, fibrinogen (Fib), white blood cell (WBC) and coronary heart disease (CHD) Is an independent risk factor for CHD. Methods: The levels of HCY, CRP, Fib and WBC were determined in 102 patients with different types of coronary heart disease and 33 healthy controls. The differences of the indexes among AMAP, UAP.SAP and control groups were compared. Results: The differences in the proportions of AMI, UAP, SPA and Control between BMI> 24 and BMI <24 showed that there was a significant difference between the two groups in male patients (P = 0.011). There was no significant difference between the two groups in female patients Difference (P = 0.28). The levels of HCY, CRP, Fib and WBC in each group were higher in AMI group than in SAP group and in AMI group and UAP group (all P <0.01) SAP group, the difference was statistically significant (P <0.05, P <0.01). The diagnostic value of CRP and WBC is better, and the diagnostic value of HCY and Fib is medium. CONCLUSION: The changes of plasma homocysteine, C-reactive protein, fibrinogen and leukocyte are closely related to the occurrence and development of coronary heart disease. Their four indexes can be used as auxiliary indexes to differentiate the type of coronary heart disease and evaluate the severity of the disease .