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目的:探讨胃窦癌病人血清细胞因子IL-10水平与发生恶病质的关系。方法:采用放射免疫法检测135例正常健康人(对照组)和150例胃窦癌病人的血清IL-10水平。结果:胃窦癌病人血清IL-10水平较对照组显著升高(P<0.01),并且血清IL-10水平胃窦癌Ⅲ、Ⅳ期明显高于Ⅰ、Ⅱ期(P<0.01)。胃窦癌恶病质的病人血清IL-10水平较非恶病质病人显著升高(P<0.01)。结论:血清IL-10水平与胃窦癌病人恶病质的发生具有相关性。
Objective: To investigate the relationship between serum IL-10 and cachexia in patients with gastric cancer. Methods: Serum IL-10 levels were measured by radioimmunoassay in 135 healthy controls (control group) and 150 patients with gastric cancer. Results: Serum levels of IL-10 in patients with gastric cancer were significantly higher than those in control group (P <0.01), and serum IL-10 levels in stage Ⅲ and Ⅳ of gastric cancer were significantly higher than those in stage Ⅰ and Ⅱ (P <0.01). Serum levels of IL-10 in patients with gastric cancer cachexia were significantly higher than those in non-cachexia patients (P <0.01). Conclusion: The serum level of IL-10 correlates with the occurrence of cachexia in patients with gastric cancer.