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有人报道由急性病毒性乙型肝炎(AVHB)转变为慢性乙型肝炎病毒感染者占5～10％。然而,新近的研究结果表明,由AVHB发展为慢性感染的病人仅为1～3％。为了评估15岁以下的AVHB患儿转变为慢性感染的发生率,作者对154例AVHB的住院患儿进行了前瞻性研究。所有患儿入院时HBsAg与IgM抗-HBs均阳性,并且于入院后3～24个月间进行观察。临床生化及血清学表现均符合急性病毒性肝炎的诊断。HBsAg、抗-HBV、抗-HAV与抗-HDV均用EIA法检测。
It has been reported from acute viral hepatitis B (AVHB) to chronic hepatitis B virus infection accounted for 5 to 10%. However, recent findings suggest that only 1 to 3% of patients develop AVHB as chronic infections. To assess the incidence of chronic infection in children under 15 years of age who have undergone AVHB, we conducted a prospective study of 154 hospitalized children with AVHB. All children were positive for HBsAg and IgM anti-HBs on admission and were observed between 3 and 24 months after admission. Clinical biochemical and serological findings are in line with the diagnosis of acute viral hepatitis. HBsAg, anti-HBV, anti-HAV and anti-HDV were detected by EIA method.