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目的 通过研究B、C基因型乙型肝炎病毒X蛋白(hepatitisBvirusXprotein ,HBx)及其变异体的功能差别 ,探讨导致B、C基因型乙型肝炎病毒相关性肝病 /癌的不同临床及病理表现机制。 方法 自GenBank查找B、C基因型乙型肝炎病毒 (hepatitisBvirus,HBV)株序列 ,选取其X基因片断并译
OBJECTIVE: To investigate the different clinical and pathological mechanisms of hepatitis B virus-associated liver diseases / cancers leading to genotypes B and C by studying the functional differences between hepatitis B and C genotypes of hepatitis B virus X protein (HBx) and their variants . Methods Genomic sequences of HBV genotypes B and C were sequenced and their X gene fragments were selected and translated