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目的观察转化生长因子β(TGF-β)及其受体在肝癌中的表达,探讨其在肝癌发病中的作用机制及临床意义。方法应用免疫组织化学SABC法对36例肝癌标本进行研究。结果TGFβ-主要分布于肿瘤细胞质中,其在肝癌中的表达率(69.25%)明显高于正常组织(19.16%)(P<0.05)。TGFβ-Ⅱ型受体主要分布于细胞膜和细胞质中,其在肝癌中的阳性表达率(34.52%)明显低于正常组织(95.83%)(P<0.01)。结论TGFβ-表达与肝癌发生、发展有密切关系,其受体表达的缺失可能是肿瘤细胞逃逸TGFβ-负调控的机制之一。
Objective To observe the expression of transforming growth factor-β (TGF-β) and its receptor in hepatocellular carcinoma, and to explore its mechanism and clinical significance in the pathogenesis of hepatocellular carcinoma. Methods Immunohistochemical SABC method was used to study 36 specimens of liver cancer. Results TGFβ- mainly distributed in the tumor cytoplasm, and its expression rate in liver cancer (69.25%) was significantly higher than that in normal tissues (19.16%) (P<0.05). TGFβ-II receptors are mainly distributed in the cell membrane and cytoplasm, and its positive expression rate in liver cancer (34.52%) was significantly lower than that in normal tissues (95.83%) (P<0.01). Conclusions The expression of TGFβ- is closely related to the occurrence and development of hepatocellular carcinoma. The lack of receptor expression may be one of the mechanisms by which tumor cells escape TGFβ- negative regulation.