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目的:研究采用二甲双胍联合格列吡嗪治疗糖尿病的疗效以及并发症。方法:选择2013年1月至2014年1月在我院接诊的120例糖尿病患者,按入院顺序分为观察组和对照组,两组患者各60例。对观察组的糖尿病患者选择二甲双胍联合格列吡嗪进行治疗,对照组的糖尿病患者则仅使用二甲双胍进行治疗。在治疗过程中学者对患者的降糖率、不良反应、空腹时的血糖以及患者的糖化血糖蛋白等记录,进行分析。结果:两组患者的疗效对比,观察组的空腹血糖降低量多于对照组的降低量,两组数据的差异存在统计学意义(P<0.05)。观察组患者的饭后2h血糖降低量明显比对照组患者的饭后2h血糖降低量,两组数据的差异存在统计学意义(P<0.05)。观察组患者的糖化血糖蛋白降低量明显比对照组患者的糖化血糖蛋白降低量(大,差异存在统计学意义(P<0.05)。结论:采用二甲双胍联合格列吡嗪治疗糖尿病能有效改善治疗效果,减少并发症的发生率。是一种有效、安全的治疗方式,值得大规模的推广使用。
Objective: To study the efficacy and complications of metformin combined with glipizide in the treatment of diabetes mellitus. Methods: From January 2013 to January 2014 in our hospital admissions of 120 cases of diabetic patients, according to the order of admission was divided into observation group and control group, two groups of 60 patients each. Patients in the observation group were treated with metformin and glipizide, while those in the control group were treated with metformin alone. During the course of treatment, the scholars analyzed the patients’ hypoglycemic rate, adverse reactions, fasting blood glucose and glycosylated glycoprotein in patients. Results: The curative effect of the two groups was compared. The decrease of fasting blood glucose in the observation group was more than that in the control group. There was a significant difference between the two groups (P <0.05). Patients in the observation group had significantly lower blood glucose levels at 2h after meal than those at 2h after meals in the control group. The difference between the two groups was statistically significant (P <0.05). The decrease of glycosylated glycoprotein in the observation group was significantly lower than that in the control group (P <0.05) .Conclusion: The treatment of diabetes with metformin and glipizide can effectively improve the therapeutic effect , Reduce the incidence of complications is an effective and safe treatment, it is worth promoting a large-scale use.