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为研究急性缺氧时的呼吸反应类型,以17名健康男性青年为受试者,在低压舱模拟3000～7000m高度上进行了45人次缺氧暴露实验。在3000～5000m高度,肺通气量(V_E)增加主要取决于潮气量(V_T),呼吸频率(f)无明显变化。在5000m,4例出现周期性呼吸,1例发生通气抑制反应。在7000m,所见呼吸反应有三种类型:(1)f持续增加,V_T减小,此型受试者均有脑功能失调症状(5例),(2)V_T和f均增加(4例);(8)V_T增加,f相对稳定(2例),该型缺氧耐力较好。
In order to study the type of respiratory reaction during acute hypoxia, 45 healthy male youths were enrolled in this study. 45 hypoxia exposure experiments were performed on the height of 3000-7000m in the low-pressure cabin. At altitude of 3000-5000m, the increase of pulmonary ventilation (V_E) mainly depends on the amount of tidal volume (V_T) and no significant change of respiratory rate (f). In 5000m, 4 patients showed periodic breathing and 1 patient developed ventilation inhibition reaction. At 7000m, there were three types of respiratory responses: (1) f increased continuously, and V_T decreased. All subjects had symptoms of brain dysfunction (n = 5), (2) increased V_T and f (n = 4) ; (8) V_T increases, f is relatively stable (2 cases), this type of hypoxia endurance is better.