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目的探讨蛋白激酶CK2β及抑癌基因蛋白p53在卵巢癌组织中的表达情况。方法选取2012年1月-2015年1月武汉市第一医院收治的卵巢肿瘤患者148例为研究对象,其中卵巢癌患者108例、良性肿瘤患者20例、交界性肿瘤患者20例,采用免疫组化法检测患者CK2β及p53在肿瘤中的阳性表达情况,分析两者表达方面的差异及其与卵巢癌患者预后的关系。结果CK2β和p53在卵巢癌患者组织中的表达均明显高于良性肿瘤及交界性肿瘤,差异均有统计学意义(P<0.05);CK2β和p53的表达均与患者的临床分期、组织分化程度、CA125水平及化疗敏感性显著相关(均P<0.05)。结论 CK2β及p53蛋白阳性表达与卵巢癌的发生发展存在密切的联系。
Objective To investigate the expression of protein kinase CK2β and tumor suppressor gene p53 in ovarian cancer. Methods A total of 148 patients with ovarian tumors admitted to the First Hospital of Wuhan from January 2012 to January 2015 were enrolled. Among them, 108 cases of ovarian cancer, 20 cases of benign tumors and 20 cases of borderline tumors were selected. To detect the positive expression of CK2β and p53 in the tumor, and to analyze the difference between them and their relationship with the prognosis of patients with ovarian cancer. Results The expressions of CK2β and p53 in ovarian cancer tissues were significantly higher than those in benign tumors and borderline tumors (all P <0.05). The expressions of CK2β and p53 were correlated with the clinical stage, histological grade , CA125 levels and chemosensitivity were significantly correlated (all P <0.05). Conclusion The positive expression of CK2β and p53 protein is closely related to the occurrence and development of ovarian cancer.