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目的观察稳心颗粒联合卡维地洛对慢性心衰合并房颤患者的影响。方法将100例慢性心衰合并房颤患者随机分为试验组与对照组各50例。2组患者均给予常规治疗控制基础疾病,如利尿剂、阿司匹林、硝酸酯类药及降压药等;试验组在常规治疗及卡维地洛的基础上再加用稳心颗粒,对照组在常规治疗基础上加用卡维地洛,比较2组治疗前后左室射血分数(LVEF)、静息心室率及临床疗效。结果治疗前,2组患者LVEF及静息心室率比较差异无统计学意义(P>0.05);治疗后2组LVEF均较治疗升高,静息心室率均较治疗前降低,且试验组LVEF与静息心室率变化幅度大于对照组,差异均有统计学意义(P<0.05)。试验组总有效率为98.0%高于对照组的88.0%,差异有统计学意义(P<0.05)。结论稳心颗粒联合卡维地洛治疗能改善慢性心衰合并房颤患者的心功能指标,减慢心室率,从而缓解其临床症状,可用于临床治疗。
Objective To observe the effect of Wenxin granule combined with carvedilol on patients with chronic heart failure and atrial fibrillation. Methods 100 patients with chronic heart failure and atrial fibrillation were randomly divided into experimental group and control group, 50 cases each. The patients in both groups were given conventional therapy to control the underlying diseases such as diuretics, aspirin, nitrates and antihypertensive drugs. The treatment group was given Wenxin Granules on the basis of routine treatment and carvedilol, On the basis of conventional treatment, carvedilol was added. The left ventricular ejection fraction (LVEF), resting ventricular rate and clinical efficacy were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in LVEF and resting ventricular rate between the two groups (P> 0.05). After treatment, the LVEF in both groups were higher than that in the treatment group, and the resting ventricular rate was lower than before treatment. The LVEF And ventricular rate of resting amplitude greater than the control group, the difference was statistically significant (P <0.05). The total effective rate of the experimental group was 98.0% higher than 88.0% of the control group, the difference was statistically significant (P <0.05). Conclusion Wenxin granule combined with carvedilol can improve cardiac function, slow down the ventricular rate in patients with chronic heart failure and atrial fibrillation, and thus relieve the clinical symptoms and can be used for clinical treatment.