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目的:探讨阿魏酸哌嗪片辅助治疗对老年慢性肺源性心脏病心力衰竭心功能及血气分析的影响,为该药安全使用提供参考。方法:按照随机抛硬币法将96例老年慢性肺源性心脏病心力衰竭患者分为对照组(常规西药治疗)与治疗组(常规西药+阿魏酸哌嗪片),共治疗8周,各48例。分别统计两组临床疗效,并于治疗前、治疗8周后检测两组心功能指标(LVEF、CI、CO、MPAP)及血气分析指标(PaO_2、PaCO_2),并观察不良反应情况。结果:两组患者治疗后各项心功能指标及血气分析指标均较治疗前显著改善,且治疗组各项指标改善程度均优于对照组,P<0.05。治疗组治疗总有效率93.75%,明显高于对照组79.17%(P<0.05);未见明显药物不良反应。结论:阿魏酸哌嗪片用于治疗老年慢性肺源性心脏病心力衰竭患者效果显著,因此可值得推广。
OBJECTIVE: To investigate the influence of piperazine ferulate on cardiac function and blood gas analysis in elderly patients with chronic cor pulmonale due to heart failure, and to provide reference for its safe use. Methods: Ninety-six elderly patients with chronic cor pulmonale heart failure were divided into control group (conventional western medicine) and treatment group (conventional western medicine + piperazine ferulate) for 8 weeks according to the random coin method. 48 cases. The clinical efficacy of the two groups were statistically analyzed. Before and after treatment for 8 weeks, the cardiac function indexes (LVEF, CI, CO, MPAP) and blood gas analysis index (PaCO 2, PaCO 2) were measured and the adverse reactions were observed. Results: After treatment, the indexes of cardiac function and blood gas analysis in both groups were significantly improved compared with before treatment, and the improvement of each index in the treatment group was better than that in the control group (P <0.05). The total effective rate of the treatment group was 93.75%, which was significantly higher than that of the control group (79.17%, P <0.05). No obvious adverse drug reactions were observed. Conclusion: Piperazine ferulate tablets are effective in the treatment of elderly patients with chronic cor pulmonale due to heart failure. Therefore, it is worthy of promotion.