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目的:观察玉香参附汤对慢性心力衰竭的临床疗效及对心衰患者舒张功能的改善作用。方法:将116例慢性心力衰竭患者随机分为两组。对照组57例予卡托普利12.5 mg,口服,每日2次,酒石酸美托洛尔12.5mg,口服,每日2次,并根据患者个体病情差异给予钙拮抗剂、利尿剂、硝酸酯类药物及降压、控制血糖等药物治疗。治疗组59例在对照组治疗基础上加用玉香参附汤口服。两组均30天为1个疗程。观察两组治疗前后症状、体征量化积分、超声心动图脉冲多普勒E/A比值、血浆BNP浓度评定临床疗效。结果:治疗组治疗后症状、体征量化积分、E/A比值、血浆BNP浓度与治疗前及对照组治疗后比较差异均有统计学意义(P﹤0.05),治疗组临床疗效总有效率93.22%。结论:玉香参附汤联合西药治疗对慢性心力衰竭患者舒张功能有显著改善作用。
Objective: To observe the clinical efficacy of Yuxiang Shen Fu Tang in patients with chronic heart failure and improve the diastolic function in patients with heart failure. Methods: 116 patients with chronic heart failure were randomly divided into two groups. 57 patients in the control group were given captopril 12.5 mg twice daily and metoprolol tartrate 12.5 mg orally twice a day. The patients were given calcium antagonists, diuretics, nitrates Drugs and antihypertensive, blood sugar and other drug control. The treatment group of 59 cases in the control group based on the use of Yu Xiang Shen Fu Tang oral. Both groups were 30 days for a course of treatment. The symptoms and signs of the two groups were observed before and after treatment, echocardiographic pulse Doppler E / A ratio, plasma BNP concentration clinical efficacy. Results: After treatment, the scores of symptom, quantification, E / A ratio and plasma BNP concentration in the treatment group were significantly different from those in the control group before and after treatment (P <0.05). The total effective rate in the treatment group was 93.22% . Conclusion: Yuxiang Shen Fu decoction combined with Western medicine can significantly improve diastolic function in patients with chronic heart failure.