作者报告用细胞毒制剂治疗13例肺部坏死性肉芽肿病(Wegener’s Granulomatosis)。3例死于本病或继发感染,1例病情缓解后死于急性心肌梗死,9例存活,2例已随访5年。 4例曾用去氢考的松无效。10例用过苯丁酸氮芥治疗,其中7例单用该药疗效满意,5例用药半年,另2例长达20个月。1例用6MP,9月后死于粒细胞缺乏症和念珠菌肺炎。4例起初服硫唑嘌呤,1例不能耐受而改服苯丁酸氮芥,3例无效而用环磷酰 The authors report the use of cytotoxic agents to treat 13 cases of Wegener’s Granulomatosis. 3 died of this disease or secondary infection, 1 died of acute myocardial infarction after remission, 9 survived and 2 were followed up for 5 years. 4 cases have been used to hydrogen test loose invalid. 10 cases were used chlorambucil treatment, of which 7 cases of the drug alone with satisfactory results, 5 cases of drug for six months, the other two cases up to 20 months. 1 case with 6MP, September died of agranulocytosis and Candida pneumonia. 4 cases initially served azathioprine, 1 case can not tolerate change service chlorambucil, 3 cases of invalid use of cyclophosphamide