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目的 :探讨血清CEA术前术后水平与胃癌生物学行为及预后的关系。方法 :应用McAbCEA -EIA法对 34例进行期胃癌患者进行术前术后对比观察及 5年随访观察。结果 :进行期胃癌血清CEA术前术后均值在淋巴结彻底清除组与未彻底清除组之间 ,浸润深度S2 以内组与S3 以上组之间 ,存活高于 3年组与低于 3年组之间比较有显著性意义 ,与胃癌的大小和组织学类型无关。结论 :胃癌患者术前术后血清CEA浓度可以发生变化 ,该变化与胃癌的淋巴结清除程度 ,胃癌浸润深度及远处转移程度有关 ,对CEA进行动态观察可以评价胃癌根治术后的近期疗效及判断预后。
Objective : To investigate the relationship between the preoperative and postoperative levels of serum CEA and the biological behavior and prognosis of gastric cancer. Methods: The McAbCEA-EIA method was used to compare preoperative and postoperative contrast observations and 5-year follow-up observations in 34 patients with advanced gastric cancer. Results: The average preoperative and postoperative values of serum CEA in patients with advanced gastric cancer were between the total lymph node depletion group and the incomplete decontamination group. The depth of invasion was less than S2 within the group and between S3 and above. The survival was higher than that of the 3-year group and less than 3 years. There was significant difference between the two groups, which was not related to the size and histological type of gastric cancer. Conclusion: The serum CEA concentration may change before and after operation in patients with gastric cancer. This change is related to the extent of lymph node clearance, invasive depth and distant metastasis of gastric cancer. Dynamic observation of CEA can evaluate the short-term efficacy and judgment of postoperative gastric cancer after radical resection. Prognosis.