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三氧化二砷作为我国中药应用已久,近年来多用于一些恶性肿瘤的治疗。在分子生物学方面,三氧化二砷诱导细胞凋亡,抑制血管内皮生长因子表达,诱导雌激素受体重新表达,逆转多药耐药;在动物实验方面,三氧化二砷和化疗药物均有较强抑瘤作用,降低微血管密度和血管内皮生长因子表达,联合用药抑瘤作用增强。现将三氧化二砷在乳腺癌方面的研究进展予以综述。
As a traditional Chinese medicine, arsenic trioxide has been used for a long time in recent years and is mostly used for the treatment of some malignant tumors. In molecular biology, arsenic trioxide induces cell apoptosis, inhibits the expression of vascular endothelial growth factor, induces estrogen receptor re-expression, and reverses multidrug resistance. In animal experiments, both arsenic trioxide and chemotherapeutic drugs have strong antitumor activity, Reduce microvessel density and vascular endothelial growth factor expression, combined with anti-tumor effect increased. Arsenic trioxide in breast cancer are now reviewed.