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微波辐射下,二氨基硫脲与乙酸反应制得3-甲基-4-氨基-1,2,4-三氮唑-5-硫酮(1),在无水乙醇中以三乙胺作为反应的缚酸剂,1与[二-(4-氟苯基)]甲基氯经微波辐射制得中间体3-甲基-4-氨基-5-[二-(4-氟苯基)]甲硫基-1,2,4-三氮唑(2),然后中间体2与芳香醛经缩合反应制得了10个Schiff碱3a～3j.合成的10个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证.
Under microwave irradiation, 3-methyl-4-amino-1,2,4-triazole-5-thione (1) was prepared by the reaction of diaminothiourea and acetic acid. Triethylamine The reaction of the acid-binding agent, 1 and [bis- (4-fluorophenyl)] methyl chloride was microwave radiation to obtain the intermediate 3-methyl-4-amino-5- [ ] Methylthio-1,2,4-triazole (2). Then, 10 Schiff bases 3a ~ 3j were obtained through the condensation reaction of intermediate 2 with aromatic aldehydes. The 10 target compounds were synthesized via melting point determination and mass spectrometry. Infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, elemental analysis confirmed its structure.