机械通气是危重症患者抢救成功的关键措施,为了提高患者气管插管及机械辅助呼吸的耐受性,必须给予必要的镇静以提高患者治疗的配合度。本文就机械通气患者镇静的必要性及镇静药物临床应用的现状,特别强调联合用药的临床应用作一综述。 Mechanical ventilation is the key to the successful rescue of critically ill patients. In order to improve the endotracheal intubation and mechanical assisted respiration, the necessary sedation must be given to improve the coordination of the patients’ treatment. In this paper, the necessity of sedation in patients with mechanical ventilation and the clinical application of sedative drugs status, with particular emphasis on the clinical application of combination therapy for a review.