在过去的几十年里,流行病的变化导致甲肝发病率大增,在发达国家这种情况尤为明显,因此促进疫苗的研究工作。最初的甲肝疫苗是福尔马林灭活病毒疫苗,以氢氧化铝作辅助剂。同时,几种同类型的疫苗也分别注册。瑞典血清和疫苗制作中心也生产出一种灭活甲肝病毒疫苗,但是以病毒颗粒作为辅助剂。新的疫苗最初是在成人志愿者身上试验。多 Over the past few decades, the epidemic has led to a dramatic increase in the incidence of hepatitis A, a situation that has become even more marked in developed countries, thus contributing to the vaccine research effort. The initial hepatitis A vaccine was a formalin-inactivated virus vaccine with aluminum hydroxide as an adjuvant. At the same time, several types of vaccines are also registered separately. The Swedish Serum and Vaccine Production Center also produces a vaccine that inactivates hepatitis A virus, but uses virus particles as an adjuvant. The new vaccine was originally tested on adult volunteers. many