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研究重症肌无力（ＭＧ）病人血清乙酰胆碱受体抗体（ＡｃｈＲａｂ）与抗骨骼肌柠檬酸提取物抗体（ＣＡＥａｂ）的含量改变及临床意义。方法以固相酶联免疫吸附法测定１２３例ＭＧ病人血清ＡｃｈＲａｂ与ＣＡＥａｂ含量。结果两种抗体的阳性率分别为７８％和２４．４％，明显高于健康献血员和非ＭＧ病人组（Ｐ＜０．０１）。ＣＡＥａｂ在合并胸腺瘤组与临床无瘤组的阳性率分别为７１％和９．８％，差别有显著性（Ｐ＜０．０１）。结论ＡｃｈＲａｂ的测定可为ＭＧ病人的早期诊断提供可靠的实验室依据，ＣＡＥａｂ的测定有助于合并胸腺瘤ＭＧ病人的早期发现。
To study the changes and clinical significance of serum AchRab and anti-skeletal muscle citric acid extract antibody (CAEab) in patients with myasthenia gravis (MG). Methods The contents of serum AchRab and CAEab in 123 MG patients were determined by solid-phase enzyme-linked immunosorbent assay. Results The positive rates of the two antibodies were 78% and 24.4%, respectively, which were significantly higher than those in healthy blood donors and non-MG patients (P <0.01). The positive rates of CAEab in combined thymoma group and clinical non-tumor group were 71% and 9.8%, respectively, with significant difference (P <0.01). Conclusion The determination of AchRab can provide reliable laboratory evidence for the early diagnosis of MG patients. The determination of CAEab is helpful for the early detection of patients with MG with thymoma.