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目的：探讨氯沙坦对２型糖尿病合并高血压患者肾功能和血压的影响。方法：７１例２型糖尿病合并高血压患者随机分为两组，氯沙坦组（３７例）：５０～１００ ｍｇ／ｄ口服，依那普利组（３４例）５～１０ ｍｇ／ｄ口服，疗程 ６个月。结果：治疗后，氯沙坦组、依那普利组血压及尿系列蛋白较治疗前有显著下降（Ｐ＜０．０１）；氯沙坦组和依那普利组血醛固酮、内皮素较治疗前明显降低（Ｐ＜ ０，０５），血管紧张素Ⅱ在依那普利组明显降低（Ｐ＜ ０．０５），氯沙坦组血尿酸显著下降（Ｐ＜０．０５）；氯沙坦不良反应轻微。结论：氯沙坦能降低２型糖尿病合并高血压患者血压，减少蛋白尿排泄，保护肾功能。
Objective: To investigate the effects of losartan on renal function and blood pressure in type 2 diabetic patients with hypertension. Methods: Totally 71 patients with type 2 diabetes mellitus complicated with hypertension were randomly divided into two groups: losartan group (37 cases) orally with 50-100 mg / d orally and enalapril group (34 cases) with 5-10 mg / d orally , Treatment for 6 months. Results: After treatment, the blood pressure and urinary protein in losartan group and enalapril group were significantly lower than those before treatment (P <0.01), and the plasma aldosterone and endothelin in losartan group and enalapril group were significantly decreased The levels of angiotensin Ⅱ in enalapril group were significantly lower than those in enalapril group (P <0.05), while the levels of serum uric acid in losartan group were significantly decreased (P <0.05) Adverse reactions to adverse reactions. Conclusion: Losartan can reduce blood pressure, reduce proteinuria and protect renal function in type 2 diabetic patients with hypertension.