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[目的]观察补肾健脾中药联合西药治疗慢性再生障碍性贫血疗效。[方法]使用随机平行对照方法,将63例住院患者按简单随机法分为两组,均基础治疗,卧床休息,贫血严重输注红细胞;出血严重止血敏等止血药物、血小板输注;合并感染者抗感染;服药后期出现肝功能损伤者予保肝药物治疗。对照组30例康力龙6mg/d或安雄40mg/d,环孢素软胶囊(华北制药)3mg/(kg.d)。治疗组33例予补肾健脾中药(黄芪30g,阿胶20g,枸杞子、黄精各15g,熟地黄10g,红景天12g,冬虫夏草5g)水煎服。观测头晕、乏力、出血及血液生化指标,12周为1疗程。连续治疗1疗程,判定疗效。[结果]治疗组基本痊愈6例,显效12例,有效13例,无效2例,总有效率93.94%。对照组基本痊愈4例,显效13例,有效7例,无效6例,总有效率80.00%。治疗组疗效优于对照组(P<0.05)。治疗6周,两组白细胞、血红蛋白和网织红细胞开始上升(P<0.05),治疗组高于对照组(P<0.05),血小板两组均变化不明显(P>0.05)。[结论]补肾健脾中药联合西药治疗慢性再生障碍性贫血,可以促进红细胞及白细胞的增生,提高机体的免疫力,较单纯西药治疗总有效率明显提高,值得临床推广应用。
[Objective] To observe the curative effect of Bushen Jianpi combined with Western medicine on chronic aplastic anemia. [Methods] Sixty-three inpatients were randomly divided into two groups according to a randomized controlled trial. All patients were treated with basic therapy, bed rest and severe anemia with erythrocytes. Serious hemostasis, hemostasis and other hemostatic drugs, platelet transfusion, combined infection Anti-infection; liver injury occurred late medication to liver protection drugs. The control group, 30 cases of Conrolon 6mg / d or Anxiong 40mg / d, cyclosporin soft capsule (North China Pharmaceutical) 3mg / (kg.d). 33 cases of treatment group to kidney and spleen Chinese medicine (Astragalus 30g, Ejiao 20g, medlar, Polygonatum 15g, Rehmannia 10g, Rhodiola 12g, Cordyceps sinensis 5g) Shuijianbi. Observed dizziness, fatigue, bleeding and blood biochemical indicators, a course of 12 weeks. Continuous treatment of a course of treatment to determine the efficacy. [Results] The treatment group basically cured in 6 cases, markedly effective in 12 cases, effective in 13 cases, 2 cases, the total effective rate 93.94%. The control group basically recovered in 4 cases, markedly effective in 13 cases, effective in 7 cases, ineffective in 6 cases, the total effective rate was 80.00%. The treatment group was better than the control group (P <0.05). After 6 weeks of treatment, the white blood cells, hemoglobin and reticulocytes in two groups began to rise (P <0.05), the treatment group was higher than the control group (P <0.05), and the platelets did not change significantly in both groups (P> 0.05). [Conclusion] Bushenjianpi combined with Western medicine in the treatment of chronic aplastic anemia can promote the proliferation of erythrocytes and leukocytes and improve the immunity of the body, which is obviously higher than the simple Western medicine, which is worthy of clinical application.