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为了探讨性激素在 SLE发病中的作用，我们采用放射免疫法检测了 20例女性 SLE患者血清睾酮 (T)、游离睾酮 (FT)、二氢睾酮 (DHT)、脱氢表雄酮 (DHEA)、雌二醇 (E2)、孕酮 (Pr)和泌乳素 (PRL)水平。结果发现患者血清 T、 FT、 DHT、 DHEA、 Pr明显低于正常对照， PRL明显高于正常对照 (P< 0.05)， E2无显著差异 (P >0.05)；未使用皮质类固醇治疗的患者血清雄激素水平也显著降低 (P< 0.05)。提示性激素异常在 SLE的发病中起了一定的作用。
To investigate the role of sex hormones in the pathogenesis of SLE, we detected the levels of serum testosterone (T), free testosterone (FT), dihydrotestosterone (DHT) and DHEA in 20 women with SLE by radioimmunoassay Estradiol (E2), progesterone (Pr) and prolactin (PRL) levels. The results showed that serum T, FT, DHT, DHEA, Pr of patients were significantly lower than those of normal controls, PRL was significantly higher than that of normal control (P <0.05), E2 was not significantly different (P> 0.05) Hormone levels were also significantly lower (P <0.05). Hormone abnormalities suggest that the pathogenesis of SLE play a role.