脓毒症在外科临床工作中较常见,治疗相当困难;本文主要概述了一氧化氮合酶的基因定位、结构特点以及一氧化氮合酶与脓毒症的关系,进一步说明由一氧化氮合酶介导的一氧化氮生成与脓毒症关系密切,而选择性一氧化氮合酶抑制剂在脓毒症各阶段恰当的应用可能是有效治疗脓毒症、降低病死率的一个重要途径,也将成为今后研究的热点。 Sepsis is more common in surgical clinical work, the treatment is quite difficult; This article describes the gene location of nitric oxide synthase, structural characteristics and nitric oxide synthase and sepsis, further elucidation of nitric oxide Enzyme-mediated nitric oxide production and sepsis are closely related, and selective nitric oxide synthase inhibitors in each stage of sepsis appropriate application may be effective treatment of sepsis and reduce mortality is an important way, It will also become a hot spot in the future.