论文部分内容阅读
Paget于1889年提出著名的种子和土壤(seedand soil)理论:扩散的肿瘤细胞只有在合适的环境下才能够生长,并导致肿瘤的转移。众多数据表明,肿瘤并不是一个简单的细胞群,而是由多种细胞组成的复杂组织,可以响应细胞内信号,感受微环境中存在的调控其生长、代谢的相关因子的刺激[1]
Paget famously proposed in 1889 the theory of seed and soil: Diffused tumor cells only grow under the right conditions and cause tumor metastases. Numerous data show that tumor is not a simple cell population, but complex tissue composed of a variety of cells that can respond to intracellular signals and experience the stimulation of the relevant factors that regulate the growth and metabolism in the microenvironment [1]