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利用C18反相柱,以0.01mol/L磷酸二氢钠(pH=2.8)-甲醇(52:48)为流动相,用α-萘酚作内标,同时测定蜂王浆制剂中10-羟基-△2-癸烯酸及其防腐剂──尼泊金乙酯和苯甲酸钠的含量,为控制药品质量提供了依据。
Using a C18 reversed-phase column, 0.01 mol/L sodium dihydrogen phosphate (pH=2.8)-methanol (52:48) as the mobile phase and α-naphthol as an internal standard, simultaneous determination of 10-fold in royal jelly preparations Hydroxy-Δ2-decenoic acid and its preservatives--the content of ethylparaben and sodium benzoate provided the basis for the control of drug quality.