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目的探讨临床早期黏膜下胃癌的淋巴结微转移和原发灶微浸润的临床意义。方法对45例早期黏膜下胃癌患者手术切除的1035个淋巴结和原发灶分别CK进行免疫组化检测并结合临床病理学指标及患者预后进行综合分析研究。结果常规HE染色,淋巴结转移率为15.6%(7/45),而CK染色为42.2%(19/45)。早期黏膜下胃癌的微转移发生率为26.7%(12/45)。45例早期黏膜下胃癌患者中,微浸润的发生率为11.1%(5/45)。5年生存率,没有微转移的患者为100%,有微转移的患者75%;没有微浸润的95%,有微浸润的患者60%。P均<0.05。结论淋巴结的微转移和原发灶的微浸润明显影响黏膜下胃癌的预后。
Objective To investigate the clinical significance of lymph node micrometastasis and primary tumor microinvasion in early submucosal gastric cancer. Methods Immunohistochemical detection was performed on 1035 lymph nodes and primary tumor in 45 patients with early submucosal gastric cancer and immunohistochemistry respectively. Combined with clinicopathological parameters and prognosis of patients, a comprehensive analysis was conducted. Results The results of routine HE staining, lymph node metastasis rate was 15.6% (7/45), while CK staining was 42.2% (19/45). The incidence of micrometastases in early submucosal gastric cancer was 26.7% (12/45). 45 cases of early submucosal gastric cancer patients, the incidence of micro-infiltration was 11.1% (5/45). The 5-year survival rates were 100% for patients with no micrometastases, 75% for patients with micrometastases, 95% for patients with no microinvasions, and 60% for patients with microinvasions. P <0.05. Conclusion The micrometastasis of lymph nodes and the microinvasion of primary tumor significantly affect the prognosis of submucosal gastric cancer.