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目的 观察钙增敏剂MCI -15 4对正常及高血压心肌肥厚大鼠心功能的效应。方法 采用大鼠离体心脏灌流的方法。结果 ①正常及心肌肥厚大鼠的主动收缩压LVDP ,LVEDP无显著性差异 ;②MCI -15 4剂量依赖性的提高了正常及心肌肥厚大鼠的收缩功能 ;③MCI -15 4可轻微改善心脏的舒张功能。结论 MCI -15 4可增强正常及心肌肥厚大鼠的心功能。
Objective To observe the effect of calcium sensitizer MCI-154 on cardiac function in normal and hypertensive rats with cardiac hypertrophy. Methods Rat heart perfusion method. Results ① There was no significant difference in active systolic pressure LVDP and LVEDP between normal and hypertrophied rats; ②MCI -15 4 increased systolic function in normal and hypertrophic rats in a dose-dependent manner; ③MCI -15 4 could slightly improve cardiac relaxation Features. Conclusion MCI-154 can enhance the cardiac function in normal and hypertrophied rats.