MicroRNAs(miRNAs)是一类在多种生物中高度保守表达的非蛋白质编码小RNA,在转录后水平调节基因表达。MiRNAs在哺乳动物心肌细胞分化增殖、血管紧张素Ⅱ1型受体表达、胰岛素分泌等生理过程中具有十分重要的意义。许多学者推测,miRNAs与心血管疾病、2型糖尿病及代谢综合征等密切相关,可作为治疗这些疾病的潜在靶点。 MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs that are highly conserved in many organisms and regulate gene expression at post-transcriptional level. MiRNAs in mammalian cardiomyocyte proliferation and proliferation, angiotensin Ⅱ type 1 receptor expression, insulin secretion and other physiological processes is of great significance. Many scholars speculate that miRNAs are closely related to cardiovascular diseases, type 2 diabetes and metabolic syndrome, and may be potential targets for the treatment of these diseases.