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本世纪30年代美国学者Von Euler发现人的精液有使子宫收缩与弛缓的双重作用,继而确定这种物质为前列腺素(PGs)。目前,已能生物合成,并相继发现有前列腺素A-I、血栓素A_2(TXA_2)与白细胞三烯(LT)系列。一、概述所有前列腺素的前体都是花生四烯酸(AA)。细胞膜磷脂受磷脂酶A_2的作用释放出AA,经环氧合酶作用生成前列腺素G_2(PGG_2),再经过氧化酶催化,使PGG_2转化为前列腺素H_2(PGH_2),PGH_2再通过前列环素合成酶和TXA_2合成酶的作用,分别在血管内皮细胞和血小板生成前列环素(PGI_2)和TXA_2。另外,AA还经脂氧合酶作用生成LT系列(详见附
In the 1930s, American scholar Von Euler found that the human seminal fluid has the dual role of contracting and relaxing the uterus, and thus confirms that this substance is prostaglandin (PGs). At present, it has been biosynthesis, and have been found to have prostaglandin A-I, thromboxane A 2 (TXA 2) and leukotriene (LT) series. First, an overview of all prostaglandin precursors are arachidonic acid (AA). Cell membrane phospholipids are released by the action of phospholipase A_2 AA, PGG 2 is produced by cyclooxygenase, and then oxidized by oxidase, PGG 2 is converted to PGH 2, PGH 2 is synthesized by prostacyclin Enzymes and TXA - 2 synthase act on prostacyclin (PGI_2) and TXA_2 in vascular endothelial cells and platelets, respectively. In addition, AA is also produced by the action of lipoxygenase LT series (see attached