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子宫颈微偏腺癌是临床上极为少见的一种子宫颈高分化腺癌,据文献统计,其仅占宫颈腺癌的1%~3%,由于该类肿瘤组织形态与正常宫颈的内膜上皮和腺体极为相似,故其缺乏特异性的临床表现和妇科检查体征;部分患者可合并黑斑息肉综合征和卵巢黏液性囊腺瘤,极易误诊和漏诊。B超声检查提示宫颈明显增粗伴宫腔积液,强化M RI可提示宫颈明显增粗,可见宫腔有液体聚集,T:加权M RI多数病例可显示多囊性病灶或非囊性的细绒毛状改变,用阿利辛/高碘酸希夫(A B/PS C)染色,可以有助于鉴别子宫颈微偏腺癌和良性宫颈病变腺体细胞。免疫染色CEA,P5 3,Ki-67三项指标,在M D A均呈阳性或强阳性表达。本文综述子宫颈微偏腺癌的临床特点,特异性辅助检查及免疫组化等在早期诊断宫颈微偏腺癌中的意义。
Cervical micro-adenocarcinoma is a clinically rare type of cervical adenocarcinoma of the highest, according to literature statistics, which accounts for only 1% to 3% of cervical adenocarcinoma, due to the type of tumor tissue and normal cervical endometrial epithelium And glands are very similar, so the lack of specific clinical manifestations and gynecological examination signs; some patients may be combined with macular polyps and ovarian mucinous cystadenoma, easily misdiagnosed and missed diagnosis. B ultrasound examination showed significant thickening of the cervix with uterine effusion, enhanced M RI may prompt significant thickening of the cervix, the liquid can be found in the uterine cavity, T: weighted M RI most cases can show polycystic lesions or non-cystic thin Variation of villi and staining with AB / PS C may help identify cervical micro-adenocarcinoma and benign cervical lesions of glandular cells. Immunostaining CEA, P5 3, Ki-67 three indicators, in M D A were positive or strongly positive expression. This review summarizes the clinical features, specific auxiliary examination and immunohistochemistry of cervical micro-adenocarcinoma in the early diagnosis of cervical micro-adenocarcinoma.