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目的:探讨血清肌钙蛋白Ⅰ(cTnⅠ)在急性肾炎(AGN)伴心力衰竭患儿中的早期表达情况及临床应用价值。方法:收集2010年1月至2013年12月期间,我院收治的AGN患儿52例,其中,22例合并心力衰竭患儿作为心力衰竭组,30例无心力衰竭患儿作为单纯AGN组,选择同期健康体检小儿30例作为对照组,比较三组的血清cTnⅠ水平。结果:心力衰竭组cTnⅠ为(1.023±0.254)ng/ml,单纯AGN组为(0.018±0.008)ng/ml,对照组为(0.011±0.006)ng/ml,心力衰竭组显著高于对照组以及单纯AGN组(P<0.05),对照组以及单纯AGN组无明显差异(P>0.05)。结论:检测血清cTnⅠ对AGN患儿是否发生心力衰竭的早期诊断具有重要意义,能够为临床诊断和治疗提供更早期和准确可靠的实验室依据,指导临床准确诊断和合理选择治疗方案。
Objective: To investigate the early expression and clinical value of serum troponin Ⅰ (cTn Ⅰ) in children with acute nephritis (AGN) accompanied by heart failure. Methods: 52 cases of AGN children admitted to our hospital from January 2010 to December 2013 were collected. Among them, 22 cases of children with heart failure as heart failure group and 30 cases of children with heart failure as AGN group, Select the same period healthy children in 30 cases as a control group, compared the three groups of serum cTn Ⅰ levels. Results: The levels of cTn Ⅰ in the heart failure group were (1.023 ± 0.254) ng / ml, (0.018 ± 0.008) ng / ml in the AGN group and 0.011 ± 0.006 ng / ml in the control group, significantly higher in the heart failure group than in the control group AGN alone group (P <0.05), the control group and simple AGN group no significant difference (P> 0.05). Conclusion: Detecting serum cTnI is of great significance for the early diagnosis of heart failure in children with AGN. It can provide an early and accurate laboratory basis for clinical diagnosis and treatment, and guide the accurate diagnosis and reasonable choice of treatment regimen.