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[目的]研究分析系统性红斑狼疮(SLE)合并结核分枝杆菌感染的特点、诊断和治疗,以提高对本病的认识和诊治水平。[方法]对56例SLE合并结核分枝杆菌感染病例的临床表现、实验室检查及诊治经过进行回顾性总结,并与同期住院的SLE非感染患者56例进行比较,采用Logistic回归等统计方法对各观察指标进行相关分析。[结果]SLE患者合并结核分枝杆菌感染以肺结核多见(43/56),起病隐匿,临床及实验室检查呈非特异,易诊为SLE活跃或其他细菌感染。相关危险因素包括既往结核病史、免疫抑制剂的使用及低蛋白血症。[结论]对有上述危险因素的SLE患者易合并结核,在治疗过程中应严密观察有无结核的活动,一旦发现,应加强抗结核治疗。
[Objective] To study the characteristics, diagnosis and treatment of patients with systemic lupus erythematosus (SLE) combined with Mycobacterium tuberculosis infection in order to improve the understanding and diagnosis and treatment of this disease. [Methods] The clinical manifestations, laboratory tests and diagnosis and treatment of 56 cases of SLE complicated with Mycobacterium tuberculosis infection were retrospectively reviewed and compared with 56 cases of non-infected SLE patients hospitalized in the same period. Logistic regression was used for statistical analysis Each observation index correlation analysis. [Results] Mycobacterium tuberculosis was common in SLE patients with pulmonary tuberculosis (43/56), occult onset, non-specific clinical and laboratory tests, and was easily diagnosed as active SLE or other bacterial infections. Related risk factors include a history of previous tuberculosis, the use of immunosuppressive agents and hypoproteinemia. [Conclusion] For patients with SLE with the above risk factors, it is easy to combine with tuberculosis. During the course of treatment, the tuberculosis activity should be closely observed. Once found, anti-TB treatment should be strengthened.