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雌孕激素受体(ER,PR)的异常表达对于子宫内膜癌的治疗、预后显著相关。表观遗传学对于肿瘤的研究显示:DNA异常甲基化参与肿瘤发生、发展过程,最新研究显示ER,PR异常甲基化与子宫内膜癌发展、预后等密切相关。阐述两种受体甲基化在子宫内膜癌组织中的研究现状,针对存在问题,提出研究方向。
The abnormal expression of estrogen and progesterone receptor (ER, PR) is significantly related to the treatment and prognosis of endometrial cancer. Epigenetics studies on tumors show that abnormal methylation of DNA is involved in tumorigenesis and progression. Recent studies have shown that abnormal methylation of ER and PR is closely related to the development of endometrial cancer and prognosis. The research status of the two kinds of receptor methylation in endometrial carcinoma was expounded, and the research directions were put forward according to the existing problems.