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目的:建立兰索拉唑肠溶微丸胶囊释放度检测方法。方法:比较不同方法对释放度曲线的真实反应程度,并对检测方法进行方法学验证。结果:建立了紫外-可见分光光度双波长法测定兰索拉唑肠溶微丸胶囊释放度。结论通过方法学验证,紫外-可见分光光度双波长法准确可靠,与高效液相色谱法比简单快捷,更适合兰索拉唑肠溶微丸胶囊释放度的测定。
Objective: To establish a method for the determination of lansoprazole enteric-coated pellets. Methods: To compare the true degree of response of different methods to the release curve, and verify the method of detection. Results: UV-visible spectrophotometric dual-wavelength method was established for the determination of lansoprazole enteric-coated pellets. Conclusion The method was verified by UV-visible spectrophotometry dual-wavelength method is accurate and reliable, compared with the high performance liquid chromatography simple and quick, more suitable for determination of lansoprazole enteric-coated pellets release.