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目的:建立利胆消炎颗粒质量标准。方法:采用薄层色谱法对制剂中黄芩、大黄、枳实、延胡索进行鉴别;采用高效液相色谱法对制剂中黄芩苷进行含量测定。结果:薄层图谱斑点清晰、分离度好、专属性强、阴性无干扰。黄芩苷进样量在30.20～181.20μg·ml~(-1)范围内与峰面积积分值呈良好线性关系(r=0.9994);平均加样回收率为98.80%,RSD=1.62%(r=9)。结论:所建标准可用于利胆消炎颗粒的质量控制。
Objective: To establish the quality standard of Choley anti-inflammatory granules. Methods: Scutellariae, rhubarb, citrus aurantium and corydalis extract were identified by TLC. The content of baicalin in the preparation was determined by high performance liquid chromatography. Results: The speckle spots of the TLC were clear, the resolution was good, the specificity was strong and the negative was non-interference. The baicalin injection showed a good linear relationship with the peak area integral value in the range of 30.20 ~ 181.20μg · ml ~ (-1) (r = 0.9994), the average recovery was 98.80% and the RSD was 1.62% (r = 9). Conclusion: The established standard can be used for the quality control of Lidan anti-inflammatory granules.