临床上常将HBeA g阴性的慢性乙型肝炎患者病毒是否复制作为是否抗病毒治疗或治疗效果评价的指标。HBV-DNA为乙肝检测金标准,但此法需要特殊设备,检测程序复杂,而且实验室要求比较高,难以适应基层医院开展,给诊断治疗带来困难。本实验通过前S1抗原(P re-S1A g)血清学检测和HBV-D Clinically, HBeA g-negative chronic hepatitis B virus replication is often used as an indicator of antiviral therapy or treatment effect. HBV-DNA is the gold standard for hepatitis B testing, but this method requires special equipment, testing procedures are complex, and the laboratory requirements are relatively high, it is difficult to adapt to the grassroots hospitals, to the diagnosis and treatment difficulties. This experiment through pre-S1 antigen (P re-S1A g) serological testing and HBV-D