本文利用大鼠大脑皮层突触膜,研究了致痫剂马桑内酯对膜Ca~(2+)、Mg~(2+)-ATP酶作用的量效、时效关系。结果表明。在6×10~(-9)mol/L-6×10~(-7)mol/L剂量范围内,酶活性明显降低,且与剂量呈明显的负相关(r=-0.992,P<0.01)。随温育时间的延长,同浓度马桑内酯降低酶活性的作用逐渐增强。本文对Ca~(2+)、Mg~(2+)-ATP酶在维持细胞钙稳态中的作用及马桑内酯致痫的可能途径进行了讨论。 In this paper, the dose-effect relationship and time-effect relationship of epileptic agent coriaria lactone on membrane Ca~(2+) and Mg~(2+)-ATPase were studied by using rat cerebral cortex synaptic membrane. The results show. In the dose range of 6×10 -9 mol/L-6×10 -7 mol/L, the activity of the enzyme was significantly decreased, and there was a significant negative correlation with dose (r=-0.992, P<0.01). ). With the prolongation of incubation time, the same concentration of coriaria lactone decreased the activity of the enzyme gradually. This paper discusses the role of Ca~(2+) and Mg~(2+)-ATPase in the maintenance of cell calcium homeostasis and the possible routes of epilepsy induced by coriaria lactone.