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为了探讨原发性肾病综合征（ＰＮＳ）患者尿中血小板活化因子（ＰＡＦ）含量变化及其意义，检测了１２例ＰＮＳ患者血、尿ＰＡＦ及尿蛋白含量。结果显示ＰＮＳ患者尿ＰＡＦ含量显著较健康对照者为高（Ｐ＜０．０１），ＰＮＳ患者与健康对照者血ＰＡＦ含量类似，表明ＰＮＳ患者尿中增加的ＰＡＦ含量，源于肾脏合成ＰＡＦ增加。尿ＰＡＦ含量与尿蛋白排泄量呈正相关（ｒ＝０．７，Ｐ＜０．０１）。研究表明：尿ＰＡＦ含量增高可作为肾小球基底膜通透性增高的指标。
In order to investigate the changes of urinary platelet-activating factor (PAF) and its significance in patients with primary nephrotic syndrome (PNS), the blood and urine PAF and urinary protein levels were measured in 12 patients with PNS. The results showed that urinary PAF levels in PNS patients were significantly higher than those in healthy controls (P <0.01). Blood PFA levels in PNS patients and healthy controls were similar, indicating that increased PAF levels in urine from PNS patients were due to increased PAF synthesis in the kidneys. Urine PAF content and urinary protein excretion was positively correlated (r = 0.7, P <0.01). Studies have shown that: increased urinary PAF content can be used as an indicator of increased glomerular basement membrane permeability.