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目的 研究胃癌患者血清新喋呤水平的变化及其与胃癌TNM分期的相关性。方法 采用酶联免疫吸附方法中的竞争抑制法测定胃癌患者 (63例 )及正常对照组 (36例 )、胃炎患者 (31例 )和癌前病变患者 (胃炎伴不典型增生 ,8例 )血清新喋呤水平。结果 胃癌及癌前病变患者血清新喋呤水平高于正常对照组及胃炎患者 (P<0.01) ;不同TNM分期胃癌患者的血清新喋呤水平差别有显著性意义 (P<0.05) ,血清新喋呤水平与胃癌TNM分期呈正相关 (P<0.01)。 结论 血清新喋呤水平的测定可能对胃癌分期及预后判断有一定意义。
Objective To study the changes of serum neopterin level in patients with gastric cancer and its correlation with TNM stage of gastric cancer. Methods The gastric cancer (63 cases) and normal control group (36 cases), gastritis (31 cases) and precancerous lesions (gastritis with atypical hyperplasia, 8 cases) were determined by competition inhibition method in enzyme-linked immunosorbent assay Neopterin level. Results Serum neopterin levels in gastric cancer and precancerous lesions were significantly higher than those in normal control group and gastritis patients (P <0.01). Serum neopterin levels in patients with different TNM staging were significantly different (P <0.05) The level of neopterin was positively correlated with TNM staging of gastric cancer (P <0.01). Conclusion The determination of serum neopterin may have some significance in staging and prognosis of gastric cancer.