目的　探讨侵袭性真菌性鼻窦炎致神经系统损害的诊断和治疗。方法　回顾性分析 9例的临床表现、影像学及病理学。结果　全部病例既往无鼻窦炎病史 ,其中 7例免疫功能低下 ,均以神经系统损害首诊于神经科 ,多呈急性暴发起病 ,病情凶险 ,表现复杂 ,以视觉障碍、头痛、偏瘫等常见。影像学和病理学提示真菌感染由鼻窦侵袭眶尖、海绵窦、颈内动脉、脑膜和脑实质等 ,鼻内窥镜检查有助于确诊 ,抗真菌药物治疗结合鼻窦切开清除术治疗 ,5例好转 ,4例死亡。结论　本病是免疫功能缺陷病人重要的致死性疾病 ,常引起严重的神经系统损害 ,应引起重视 Objective To investigate the diagnosis and treatment of nervous system damage caused by invasive fungal sinusitis. Methods Retrospective analysis of 9 cases of clinical manifestations, imaging and pathology. Results All patients had no history of sinusitis in the past. Among them, 7 patients were immunocompromised. All patients were initially diagnosed with neurological damage in neurology. Most of them were acute outbreaks, their disease was dangerous and the performance was complicated. Visual impairment, headache and hemiplegia were common. Imaging and pathology suggest fungal infection from the sinus orbital apex, cavernous sinus, internal carotid artery, meninges and brain parenchyma, nasal endoscopy can help confirm the diagnosis, anti-fungal drug treatment combined with sinus resection and removal of treatment, 5 Cases improved, 4 patients died. Conclusion The disease is an important fatal disease in patients with immune deficiency, often cause serious nervous system damage, should pay attention