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目的总结艾滋病病毒的耐药性,并对其耐药性影响因素深入分析。方法选取进入医院的艾滋病确诊患者167例进行研究,根据患者是否接受抗病毒治疗进行分组,对照组67例未进行抗病毒治疗,观察组100例接受抗病毒治疗,以横断面调查方法及基因型分析法,对2组感染患者进行病毒耐药性测定并比较结果。结果 167例患者的病毒载量均已超过1 000 copies/ml;对照组病毒耐药率为2.99%,观察组病毒耐药率为18.00%,2组比较差异有统计学意义(P<0.05)。结论当艾滋病患者出现基因突变后,即会引起病毒耐药性,而为提高其治疗效果,需要督促患者合理用药,并指导患者定期接受耐药性临床测定工作,再结合患者检测结果调整用药类型,从而进一步提高用药效果与合理性。
Objective To summarize the HIV drug resistance and to analyze its influencing factors. Methods One hundred and sixty-seven AIDS-diagnosed patients admitted to the hospital were enrolled and divided into groups according to whether they received antiviral therapy or not. 67 patients in the control group were not treated with antiviral therapy and 100 patients in the observation group received antiviral therapy. The cross-sectional investigation and genotype Analysis, the two groups of patients infected with virus resistance determination and comparison results. Results The viral load in 167 patients was more than 1 000 copies / ml, the control group was 2.99%, the observation group was 18.00%, the difference was statistically significant (P <0.05) . Conclusion When AIDS patients have gene mutation, it will cause virus resistance, and in order to improve its therapeutic effect, it is necessary to urge patients to use drugs rationally and instruct patients to receive regular clinical trials of drug resistance. Combined with the patient test results to adjust the type of drug , So as to further improve the efficacy and rationality of medication.