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目的:建立珍视明滴眼液中硼砂、硼酸及总硼的含量测定方法。方法:结合微量滴定法与常量滴定法测定珍视明滴眼液中硼砂、硼酸及总硼的含量。结果:硼砂的线性范围为8～16 mg,线性方程Y=504.52X-0.14(r=0.998 8),加样回收率为98.29%(n=6,RSD 1.37%)。硼酸的线性范围为50～70 mg,线性方程Y=141.74X+0.07,(r=0.999 7),加样回收率为97.02%(n=6,RSD 0.78%)。总硼的线性范围在0.8～1.2 mmol,线性方程Y=9.51X-0.05(r=0.999 7),加样回收率为95.29%(n=6,RSD 0.75%)。结论:该方法简单、准确度高、易于推广,可用于珍视明滴眼液的质量评价。
Objective: To establish a method for the determination of borax, boric acid and total boron in Zhenzhongming Eye Drops. Methods: The contents of borax, boric acid and total boron in Zhenzhengming Eye Drops were determined by microtitration and constant titration. Results: The linear range of borax was 8-16 mg. The linear equation was Y = 504.52X-0.14 (r = 0.998 8). The recovery rate was 98.29% (n = 6, RSD 1.37%). The linear range of the boric acid was 50-70 mg. The linear equation was Y = 141.74X + 0.07 (r = 0.999 7). The recovery was 97.02% (n = 6, RSD 0.78%). The linear range of total boron is 0.8 ~ 1.2 mmol, the linear equation Y = 9.51X-0.05 (r = 0.999 7), and the average recovery is 95.29% (n = 6, RSD 0.75%). Conclusion: The method is simple, accurate and easy to popularize. It can be used to evaluate the quality of Ming Eye Drops.