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目的 观察雷公藤多苷治疗前葡萄膜炎的临床效果。方法 随机选择 4 6例 5 4眼前葡萄膜炎 ,给以口服雷公藤多苷 ,初剂量 2 0mg/次 ,3次 /d ,炎症控制后减为 10～ 2 0mg/次 ,1～ 2次 /d ,维持 2～ 4个月 ,局部用激素性眼水点眼及阿托品眼水散瞳 ,观察眼部炎症消退情况及全身副作用的发生情况。结果 多数病人在雷公藤治疗 1周后炎症开始减轻 ,2～ 3周后炎症基本控制 ,随访 3个月至 1年 ,2例复发 ,仍用雷公藤治愈。治疗期间未出现其他副作用。结论 雷公藤多苷可代替激素治疗前葡萄膜炎且疗效肯定 ,尤其是对伴有糖尿病、溃疡病等不适宜用激素治疗者以及对激素已经产生依赖性的复发病人其实用意义更大。
Objective To observe the clinical effect of tripterygium glycosides before treatment of uveitis. Methods Forty-six cases of anterior uveitis were randomly selected. The initial dose of tripterygium wilfordii was given orally with tripterygium glycosides. The initial dosage was 20 mg / time, 3 times / d. The inflammation was reduced to 10-20 mg / d, to maintain 2 to 4 months, topical eye drops with atropine and atropine eye water dilated eye inflammation subsided and the occurrence of systemic side effects. Results Most patients began to reduce inflammation after 1 week of treatment with Tripterygium wilfordii. The inflammation was basically controlled after 2 to 3 weeks. The patients were followed up for 3 months to 1 year. Two patients relapsed and were still cured with Tripterygium wilfordii. No other side effects occurred during treatment. Conclusion Tripterygium glycosides can replace hormone treatment of anterior uveitis and have a positive effect, especially for patients with diabetes, ulcer disease is not suitable for hormone therapy and hormone-dependent relapse patients have more practical significance.