目的:系列检测50例肝硬化患者血浆凝血因子,分代偿期与失代偿期两组,并分别探索其临床意义。方法:凝血因子抗原测定采取火箭电泳法,凝血因子活性测定采取一期凝血法或发色底物法。结果:除凝血因子Ⅶ活性升高外,其余各凝血因子的抗原性与活性均呈不同程度的降低。其中失代偿期因子Ⅴ与纤维蛋白原的降低显著。结论:因子Ⅴ降低见于肝硬化失代偿期,其降低表明病情恶化与预后不良。 Objective: To detect 50 patients with cirrhosis of plasma coagulation factor, sub-decompensated and decompensated two groups, and to explore its clinical significance. Methods: The determination of clotting factor antigens using rocket electrophoresis, clotting factor activity assay to take a coagulation or chromogenic substrate method. Results: In addition to the activity of coagulation factor Ⅶ increased, the rest of the blood coagulation factor antigenicity and activity were decreased to varying degrees. The decompensation factor Ⅴ and fibrinogen decreased significantly. CONCLUSIONS: Factor V reduction is found in decompensated liver cirrhosis, and its decrease indicates poor disease progression and poor prognosis.