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作者应用12种不同剂量的氯霉素治疗525例伤寒病人,三組病人每天氯霉素之剂量各为每公斤31.6毫克,47.4毫克和62.8毫克,分成4或6次应用,疗程为5天,另三組每天之剂量減少一半各为每公斤15.6毫克,23.7毫克和31.6毫克,分成3或4次应用,疗程10天。另六組之剂量同前二組,但加用Prednisolone剂量为每公斤0.8毫克,一天三次,应用3天。治疗結果,10天疗程組中其并发症发生率最高者較5天疗程組中最低者还要低,加用Prednisolone組和未应用
The authors used 12 different doses of chloramphenicol in the treatment of 525 patients with typhoid fever. The daily doses of chloramphenicol in each of the three groups were 31.6 mg / kg, 47.4 mg / kg and 62.8 mg / kg, divided into 4 or 6 doses of 5 days, The other three groups daily dose reductions of 15.6 mg / kg, 23.7 mg / kg and 31.6 mg / kg were divided into 3 or 4 applications for 10 days. The other six groups of the same dose as the first two groups, but plus Prednisolone dose of 0.8 mg per kilogram, three times a day for 3 days. The results showed that the highest incidence of complications in the 10-day course was lower than the lowest in the 5-day course, with Prednisolone plus no application