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以辛二酸为原料,经过LiAlH_4还原,得到1,8-辛二醇,再用Ag_2CO_3硅藻土选择性氧化得8-羟基辛醛,最后用乙酸酐乙酰化,与丙二酸缩合,水解得到目的化合物10-羟基-2-癸烯酸。其结构经~1H-NMR、IR分析所证实。
Suberic acid was used as raw material to get 1,8-octanediol after reduction with LiAlH_4, then 8-hydroxyoctanal was selectively oxidized with diatomaceous earth of Ag_2CO_3 and finally acetylated with acetic anhydride to condense and hydrolyze with malonic acid The target compound 10-hydroxy-2-decenoic acid was obtained. The structure was confirmed by ~ 1H-NMR and IR analysis.