Metallic nano multilayers were usually prepared by dual targets alternating deposition method.In this paper,a series of self-assembled Cu-W nano multilayers with different modulation periods were deposited on single crystal silicon substrate by dual targets confocal magnetron sputtering technique.The self-assembled film pre-sented an alternation of W-rich layer and Cu-rich layer.The degree of coherence of the layered interface can be adjusted by controlling both the solid solubility of W-rich and Cu-rich layers.The film resistance increment of the self-assembled Cu-W multilayers is only 14％ when the modulation period decreases from 68.2 nm to 5.3 nm,having less size effect compared to the film prepared by alternating deposition method.It noticed that the film resistance even decreased slightly when the modulation period decreased to below 5.3 nm.These results sug-gested that the coherence could weak the interface scattering ability to electrons,so the self-assembled Cu-W multilayers have lower resistance than the multilayer prepared by alternating deposition technique.This study presented a new pathway to enhance the conductivity of the multilayers.