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目的探讨小剂量阿司匹林对影响多囊卵巢综合征患者妊娠结局部分不良因素的作用。方法选择2012年1—5月来我院门诊就诊的多囊卵巢综合征(PCOS)患者为研究对象,所有研究对象均纠正异常激素水平后随机分为二组,观察组首先给予口服小剂量阿司匹林50mg/d,连续3个月后行促排卵指导受孕。对照组未用药物治疗直接促排卵治疗并指导受孕,对二组的妊娠率及其影响因素进行分析。结果观察组的临床妊娠率为29.2%,对照组的临床妊娠率为17%,二组患者的妊娠率比较差异有统计学意义(P<0.05)。Logistic分析显示,肥胖、胰岛素抵抗、高血脂、内膜评分异常是非用药组导致妊娠失败的危险因素。肥胖、高血脂是观察组导致非妊娠的危险因素。结论 PCOS患者规范的给予小剂量阿司匹林,可以改善影响PCOS患者妊娠的不良因素,从而提高妊娠率。
Objective To investigate the effect of low-dose aspirin on adverse pregnancy outcomes in patients with polycystic ovary syndrome. Methods Patients with polycystic ovary syndrome (PCOS) from January to May 2012 in our hospital were selected as study subjects. All subjects were corrected for abnormal hormone levels and then randomly divided into two groups. The observation group was given oral low dose aspirin 50mg / d, 3 months after the line ovulation guide pregnancy. The control group did not use drugs directly to promote ovulation therapy and guide the pregnancy, the pregnancy rate of the two groups and its influencing factors were analyzed. Results The clinical pregnancy rate was 29.2% in the observation group and 17% in the control group. There was significant difference in pregnancy rate between the two groups (P <0.05). Logistic analysis showed that obesity, insulin resistance, hyperlipidemia and endometrial score abnormalities were risk factors for non-medication-induced pregnancy failure. Obesity, hyperlipidemia were the risk factors of non-pregnancy in observation group. Conclusion PCOS patients given low-dose aspirin can improve the adverse factors affecting the pregnancy in patients with PCOS, thereby increasing the pregnancy rate.