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长期滥用解热镇痛剂引起尿路癌长期滥用含非那西丁、阿司匹林、安替比林、咖啡因等药物的解热镇痛剂的病人常引起肾乳头坏死、非阻塞性肾炎等肾脏损害。近年来注意到发生上述肾脏病变的病人其肾盂癌及膀胱癌发生率很高。据一个统计资料,将近6000名非滥用解热镇痛剂的慢性肾病病人其肾盂癌发生率为0.7%,而长期滥用解热镇痛剂发生肾脏病变病人的肾盂癌发生率远远超过这一数字,如104名滥用解热镇痛剂发生肾脏病变的病人中9人发生肾盂癌,另2人发生膀胱癌;在20名肾盂癌病人中5人为滥用解热镇痛剂者。另一组15例肾盂癌中10例系滥用解热镇痛剂者,另2例膀胱癌亦为滥用解热镇痛剂者。长期滥用解热镇痛剂引起的肾盂癌,大多数属于乳头瘤或实体瘤,少数为混合型瘤。很多例乳头瘤为
Long-term abuse of antipyretic analgesics cause urinary tract cancer Long-term abuse of patients with phenacetin, aspirin, antipyretics and analgesics such as caffeine and other drugs often cause renal papillary necrosis, non-obstructive nephritis and other kidneys damage. In recent years, noted that the incidence of renal disease in patients with renal pelvis and bladder cancer high incidence. According to one statistic, the incidence of renal pelvic cancer in nearly 6,000 patients with chronic kidney disease who do not use antipyretic analgesics is 0.7%, while the incidence of renal pelvic cancer in patients with long-term abuse of antipyretic and analgesic agents is much higher than this Figures such as 104 of renal dysplasia with abuse of antipyretic and analgesic occurred in 9 patients with renal pelvis cancer, the other two were bladder cancer; in 20 patients with renal pelvic cancer abuse abuse analgesics. Another group of 15 cases of renal pelvis cancer in the abuse of antipyretics and analgesics were the other two cases of bladder cancer is also abuse of antipyretic analgesics. Long-term abuse of antipyretic analgesics caused renal pelvis cancer, most of the papilloma or solid tumors, a small number of mixed tumors. Many cases of papilloma